Director - medicinal chemistry

Natick, Massachusetts

Position closed

We seek a talented Director or Senior Director to lead medicinal chemistry within a dynamic and interdisciplinary team of scientists to develop new therapeutics for unmet medical needs. Key responsibilities will include executing medicinal chemistry strategy and SAR studies along with management of external and internal resources. Experience with computational design and analysis tools is highly desirable and a background in medicinal chemistry of kinases, DNA binders and transcriptional targets will be an advantage.

  • Serve as a medicinal chemistry team leader across multiple programs
  • Lead programs up to IND-enabling studies, including structure-based drug design
  • Provide scientific direction and leadership for synthetic and medicinal chemistry activities of internal and external FTEs
  • Supervise and direct synthetic chemistry activities at contract research organizations (CROs)
  • Participate in decision-making processes within project teams by actively engaging in scientific and technical discussions
  • Communicate (both in writing and verbally) project status, issues, schedules and accomplishments to various management and stakeholder groups in an effective manner
  • Critically evaluate project data while rigorously driving data-driven Go/No-go decisions, including the identification of resource constraints and bottlenecks
  • Direct medicinal chemistry resources for one or more drug discovery projects, working in concert with colleagues in biology, pharmacology, computational chemistry, ADME, and other key functions
  • Promote a group culture of agility, pro-action, collaboration, and innovation
  • Ph.D. in a related scientific field
  • 8 – 10 years of drug discovery experience, including at least 3 years of experience managing a team of scientists
  • Strong skills and proven track record in areas of medicinal chemistry
  • Demonstration of highly successful project execution across disease areas using in-house and/or CRO resources leading to preclinical candidates for further clinical development
  • A track record of delivering clinical candidates, highly motivated, creative, and devoted to project goals
  • Impeccable attention to detail, and excellent ability to perform hands on experiments, research/design/organize projects and maintain detailed documentation
  • Able to provide leadership on a cross-functional team
  • Strong organizational skills and the ability to manage multiple tasks
  • Possess effective verbal, written, and interpersonal communication skills