Senior scientist - biology

Natick, Massachusetts

Position closed

We seek a highly motivated cancer biologist to join our early drug discovery team in Natick, Massachusetts. The successful candidate will play a key role in target validation. She/He will use genetic and pharmacological perturbations in mammalian cells to discover and confirm candidates for novel therapeutics and test mechanistic hypotheses in disease relevant models. The successful candidate will support novel drug discovery projects at all stages of drug development and provide translational support as projects move into clinical development.

  • Design, optimize, and perform cellular assays to support drug discovery efforts in cancer biology
  • Validate novel therapeutic targets using genetic and pharmacological approaches
  • Perform experiments to drive in-depth understanding of mechanism-of-action and biomarker identification
  • Conduct internal high-throughput screening
  • Summarize and analyze data packages, and present findings at project meetings
  • Keep up to date with the latest advances in biotechnologies and oncology research
  • MS/PhD in Molecular or Cell Biology, Genetics, or a related field
  • 3+ years of experience in conducting laboratory research in oncology, with an expertise in genetic perturbation (CRISPR and RNAi)
  • Experience in the design, execution, and optimization of cellular and molecular assays
  • Experience with a variety of molecular and cellular biology techniques, such as DNA and RNA manipulation, ELISA, Western blot, flow cytometry, and immunofluorescence
  • Experience with high-throughput platforms is strongly preferred
  • Excellent communication and interpersonal skills, including the ability to provide timely and open feedback
  • Ability to present experimental data to diverse audiences such as project teams and leadership
  • Strongly self-motivated, detail-oriented, ability to multi-tasking; proficient reasoning skills in experimental design, data analysis, and interpretation
  • Critical problem-solving capabilities; a flexible team-oriented perspective, and ability to work in a fast-paced, highly collaborative environment