Principal scientist - biochemistry

Natick, Massachusetts

Position closed

Allorion therapeutics is seeking an experienced scientist to join our Biochemistry department to lead our small molecule drug discovery efforts. The successful candidate will play a key role in planning and executing hit finding strategies. He/she must be highly skilled in biochemical and biophysical assay development and mechanistic enzymology. The candidate will work closely with colleagues across different disciplines to support and expand Allorion drug discovery portfolio.

  • Contribute to experimental design and development of biochemical and biophysical assays to characterize enzymes
  • Lead hit finding efforts to enable hit discovery and understand mechanism of small molecule modulation
  • Evaluate new technologies and vendors to expand drug discovery capability
  • Work closely with external research organizations to generate quality data within timeline
  • Assess and interpret data to make data-driven decisions and regularly present to scientific, project and leadership teams
  • Collaborate with chemistry and biology colleagues to validate compound data, drive mechanistic understanding of small molecule hits and guide hit to lead and lead optimization activities
  • Create a learning environment for open discussion and suggestions. Foster a team culture of ownership and ensure recognition of team achievements
  • Ph.D. in Enzymology, Biochemistry, Molecular Biology, or related field, plus over 10 years of laboratory experiences in small molecule drug discovery
  • Expertise in in vitro biochemical and biophysical assay design and development. Familiar with variety of detection technology including FRET, FP, fluorescence, luminescence, etc.
  • Experience in high throughput screening desired
  • Expert knowledge of enzymology
  • Strong organization and planning skills
  • Excellent written and verbal communication skills. Must be able to clearly present complex enzymatic reactions to others in both formal and informal settings
  • Experience working with external research organizations strongly desired
  • Experience with protein engineering and purification desired
  • Ability to work independently as well as to collaborate with peers